Job Description The Executive Director, Commercial Analytics — Global Forecasting will lead the integrated global forecasting capability within Global Commercial Strategy. Reporting to the Vice President, Global Commercial Analytics, this leader will be accountable for the quality, consistency, and strategic use of forecasts across the broad Vertex portfolio, spanning early pipeline, pre-launch, launch, lifecycle, and in-line products. This is a senior enterprise leadership role with responsibility for establishing forecasting standards, governance, methodologies, and talent across the organization. The Executive Director will be a key owner of the annual Long-Range Planning (LRP) process, working closely with the Senior Vice President, Global Commercial Strategy, Corporate Finance, disease leaders, regions, and Manufacturing and Supply Chain to produce an integrated global revenue outlook and translate it into portfolio, investment, and supply-planning implications. Key Duties & Responsibilities Lead the Global Forecasting organization and capability agenda across pipeline, pre-launch, launch, lifecycle, and in-line disease areas. Own the integrated global revenue outlook for the Vertex portfolio, including underlying market, patient, access, competitive, clinical, regulatory, pricing, and commercial assumptions. Co-lead the annual LRP revenue forecasting process with GCS leadership and Corporate Finance, establishing the process, calendar, deliverables, governance, and executive decision points. Integrate disease-area forecasts into a coherent portfolio view and clearly communicate value drivers, sensitivities, risks, opportunities, uncertainties, and implications for investment. Establish enterprise forecasting standards, including model architecture, assumptions, scenario frameworks, documentation, quality control, version management, review expectations, and approval governance. Create a connected forecasting model across global and regional processes, ensuring near-term in-line forecasts and longer-range global forecasts use aligned assumptions, transparent transitions, and clearly defined accountabilities. Partner with Manufacturing and Supply Chain to translate commercial forecasts into demand and capacity-planning inputs, including appropriate scenarios, ranges, timing, and updates at material inflection points. Ensure forecasts are refreshed when material clinical, regulatory, competitive, access, market, or supply information changes the outlook or the decisions the forecast must support. Build base, upside, downside, and alternative scenarios that quantify key uncertainties and enable strategic, portfolio, launch, capital-allocation, and supply decisions. Ensure forecasts integrate evidence from Market Research, Decision Science, Competitive Intelligence, epidemiology, HEOR, Value & Access, Medical, Development, and external data sources. Provide objective forecasting leadership to disease teams and senior governance forums, pressure-testing assumptions and translating complex outputs into clear recommendations. Establish fit-for-purpose forecasting approaches across different lifecycle stages, from early opportunity assessments and commercial due diligence through launch and mature in-line products. Build scalable forecasting tools, templates, data structures, and reporting mechanisms that improve transparency, comparability, agility, and reuse across the portfolio. Select and manage external forecasting partners where specialized capacity is needed while maintaining internal ownership of methodologies, assumptions, interpretation, and quality. Build, develop, and retain a high-performing global forecasting team with strong technical depth, portfolio perspective, business judgment, and executive communication capability. Measure forecast performance, process effectiveness, stakeholder confidence, and decision impact; use lessons learned to continuously improve models, standards, and ways of working. Required Education Level Minimum of a Bachelor’s degree in business, economics, finance, statistics, mathematics, operations research, life sciences, engineering, or a related discipline. Advanced degree such as an MBA, M.S., Ph.D., or other relevant qualification preferred. Required Experience Extensive leadership experience in biopharmaceutical forecasting, commercial analytics, strategic planning, or a closely related discipline. Demonstrated success leading forecasting across a broad portfolio that includes both in-line products and pipeline assets at multiple stages of development. Deep expertise in global revenue forecasting, patient-based and market-based models, scenario planning, uncertainty assessment, analog selection, assumption development, and model governance. Significant experience leading long-range planning and partnering with senior Commercial and Corporate Finance leaders on portfolio, investment, and enterprise planning decisions. Experience integrating global, regional, and local forecasting processes and reconciling near-term operational forecasts with long-range strategic forecasts. Experience partnering with Manufacturing and Supply Chain and translating commercial forecasts into demand, capacity, and supply-planning implications. Experience supporting commercialization decisions across early pipeline, pre-launch, launch, lifecycle management, and established in-line businesses. Demonstrated ability to establish forecasting standards, common methodologies, governance, tools, and quality controls across a complex global organization. Proven success building and leading high-performing forecasting teams through senior leaders and influencing effectively in a highly matrixed environment. Exceptional strategic judgment, analytical rigor, financial and commercial acumen, executive communication, and ability to constructively challenge assumptions while building alignm At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

Executive Director, Commercial Analytics — Global Forecasting.

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