Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. We are seeking a Senior Manager, Accounting to join our finance team. The ideal candidate will have a strong fundamental understanding of U.S. GAAP and experience managing general ledger accounting and financial close activities. Experience within the pharmaceutical, biotechnology, or life sciences industry is strongly preferred. The Senior Manager, Accounting will play a key role in overseeing the monthly, quarterly, and annual close process and ensuring the accuracy, completeness, and integrity of the Company’s financial records. This position will oversee accounting activities across several areas, including cash, investments, fixed assets, prepaid expenses, accruals, leases, and equity. The Senior Manager will perform primary-level reviews of journal entries and account reconciliations, support the Company’s SOX compliance program, and partner with internal and external stakeholders on accounting and audit matters. This leadership role will also partner with our Financial Systems and Operations team to support our broader finance data strategy and will work collaboratively with Chief Accounting Officer’s leadership team to enable process optimization and global financial process ownership for the record to report cycle. The successful candidate will possess strong leadership capabilities, exceptional organizational skills, and excellent written and verbal communication skills. This individual will also be responsible for developing and mentoring members of the accounting team while supporting special projects, and other strategic initiatives. Key Responsibilities: Manage assigned aspects of the monthly, quarterly, and annual general ledger close process, ensuring activities are completed accurately and in accordance with established deadlines. Oversee accounting activities for areas including cash, investments, fixed assets, prepaid expenses, accruals, leases, and equity. Perform primary-level review of journal entries, account reconciliations, supporting schedules, and accounting analyses to ensure accuracy, completeness, appropriate supporting documentation, and compliance with U.S. GAAP and Company policies. Maintain a strong understanding of assigned balance sheet and income statement accounts and proactively identify unusual activity, reconciling items, trends, and accounting matters requiring further analysis. Oversee and support the execution and documentation of SOX controls and assist in enhancing internal controls and procedures to ensure compliance with SOX requirements and Company policies. Support internal and external audit activities, including preparation and review of requested schedules, documentation, and supporting materials. Partner cross-functionally with FP&A, Treasury, Legal, Tax, HR, and other departments to ensure transactions are appropriately accounted for and financial information is complete and accurate. Identify and implement opportunities to improve accounting processes, strengthen controls, increase efficiency, and enhance the scalability of the financial close process. Manage, mentor, and develop accounting team members, including establishing performance expectations, providing ongoing feedback and coaching, and supporting professional development and career growth. Foster a collaborative, accountable, and high-performing team environment. Lead and participate in special projects, including financial close acceleration, automation of accounting initiatives, global process improvements, system implementations and enhancements, and other strategic finance projects. This will include enablement and governance of our finance data strategy in partnership with our Finance Systems and Operations team. Stay current on relevant accounting standards and regulatory requirements and evaluate their potential impact on the Company. All activities of this position will be performed in conformance with established Company policies as well as GAAP, SOX, and other applicable regulatory requirements. Other ad-hoc projects and responsibilities as needed. Requirements: Bachelor’s degree in Accounting, Finance, or related field required; CPA strongly preferred. 8+ years of accounting experience, including significant experience with general ledger accounting and financial close activities. Public company and/or public accounting experience required. Experience with SOX compliance and internal controls over financial reporting required. Experience reviewing journal entries, account reconciliations, and supporting accounting analyses required. Experience with accounting for multiple balance sheet areas, including cash, investments, fixed assets, prepaid expenses, accruals, leases, and/or equity required. Pharmaceutical, biotechnology, or life sciences industry experience strongly preferred. Strong understanding of U.S. GAAP and demonstrated ability to research and apply accounting guidance. Working knowledge of ERP (i.e. Netsuite) solutions, close management tools (i.e. Blackline or similar), advanced automation/AI solutions, and advanced excel skills strongly preferred. Demonstrated learning mindset, strong analytical, and problem-solving skills. Exceptional organizational skills with proven ability to manage multiple priorities and deadlines effectively. Meticulous attention to detail with a commitment to accuracy and quality. Excellent written and verbal communication skills, with the ability to effectively communicate accounting matters to finance and non-finance stakeholders. Strong leadership, coaching, and team-development skills. High ethical standards and a commitment to maintaining the confidentiality of sensitive financial information. Ability to adapt and operate effectively in a fast-paced, dynamic environment. Ability to work independently while collaborating effectively as part of a team. Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $138,600 - $169,400 per year. We comply with all applicable minimum wage laws. All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected]. Join our growing team focused on transforming the treatment of people with liver diseases. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Senior Manager – Accounting.

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