Job Description At Vertex, we're relentless in our pursuit of scientific innovation to create transformative medicines for people with serious diseases. Our Hematology organization supports patients living with transfusion-dependent beta thalassemia (TDT) and sickle cell disease (SCD) through an established gene therapy product. This team is focused on sustaining momentum, expanding impact, and delivering a consistent, high-quality experience for patients, caregivers, healthcare professionals, and treatment centers. With the support of a global biotech company and the opportunity to help shape the continued evolution of Hematology, this Senior Director of Hematology role will contribute directly to strong performance and delivering innovation for patients living with serious hematologic diseases. The Senior Director of Hematology - West will lead the field-based customer engagement organization across the current commercial model, including Gene Therapy Account Managers (GTAM) and Hematology Territory Managers (HTM) across Michigan, Texas to California. The Senior Director of Hematology - East will lead the field-based customer engagement organization across the current commercial model, including Gene Therapy Account Managers (GTAM) and Hematology Territory Managers (HTM) across the East Coast from Maine to Florida. The incumbent(s) will be responsible for setting strategy, translating business priorities into disciplined field execution, and building the capabilities required to sustain and advance performance. Primary responsibilities include leading, coaching, mentoring, and developing both teams; optimizing coordination across authorized treatment centers, referring providers, and community-based territories; and collaborating with internal and external partners deliver positive customer experiences. The incumbent will be responsible for setting strategy, translating business priorities into disciplined field execution, and building the capabilities required to sustain and advance performance. Primary responsibilities include leading, coaching, mentoring, and developing both teams; optimizing coordination across authorized treatment centers, referring providers, and community-based territories; and collaborating with internal and external partners deliver positive customer experiences. Key Duties and Responsibilities: Executes national Hematology field strategy across authorized treatment centers, referring providers, and community-based team members Leads, coaches, develops, and manages field teams (GTAM/HTM) Ensures strong, compliant coordination between field teams to connect treatment-center engagement, community-based customer needs, and the end-to-end patient journey Translates business priorities into clear field objectives, account and territory plans, performance expectations, and measurable outcomes Optimizes team structure, geographic coverage, resource allocation, and ways of working to sustain performance and expand patient impact Oversee day-to-day field execution, including customer engagement, territory and account planning, coaching, performance management, and cross-functional coordination Provides timely verbal and written feedback based on performance reviews, coaching observations, customer insights, key performance indicators, and demonstrated behaviors Builds team capability through onboarding, ongoing training, leadership development, and sharing of best practices across treatment-center and community-based roles Partners across cross-functional stakeholders to remove barriers and deliver a consistent customer experience Uses business performance, customer insights, and patient-journey indicators to identify opportunities, adapt strategy, and drive continuous improvement Coordinates and facilitates regular business reviews with leadership and cross-functional stakeholders, ensuring clear decisions, accountability, and follow-through May perform other duties as assigned or as business needs evolve. Role models and instills a culture of compliance focused on ethics and integrity in all we do Knowledge and Skills: Understands cGMP, FDA compliance, and Mfr. guidelines Experience in working/leading cross-functional teams to coordinate and execute plans and projects across relevant stakeholders(s) is strongly preferred, e.g., Account Management, Medical Exhibits strong leadership skills in coaching and motivating others under direct supervision and within matrix environment; demonstrated leadership in driving change. Education and Experience: Bachelor’s degree in relevant discipline 12 years’ experience of the equivalent combination of education and experience 7 years’ experience in healthcare industry 3 years people management experience At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $228,000 - $342,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

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