Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Vice President, Commercial & Medical Affairs IT Business Partner will lead Madrigal’s Commercial and Medical Affairs IT Business Partnership, supporting the company’s global Commercial and Medical Affairs organizations. This role will serve as the senior IT partner to the Commercial and Medical Affairs executive leadership teams, translating functional strategy into technology roadmaps, portfolio priorities, operating capabilities, and delivery outcomes. As Madrigal continues to scale as a commercial-stage company, the technology needs across Commercial and Medical Affairs are becoming more complex, interconnected, global, and critical to the company’s ability to execute. This leader will help mature how IT supports the customer, patient, provider, payer, and medical engagement ecosystem, ensuring the right systems, data, integrations, processes, partners, and internal capabilities are in place to support commercial execution, market access, patient services, field effectiveness, omnichannel engagement, medical education, field medical excellence, and continued operational scale. This is a senior leadership role that requires deep life sciences technology experience, strong executive influence, and the ability to operate across strategy and execution. The VP will own the Commercial and Medical Affairs IT portfolio, budget, roadmap, application landscape, and business partnership model, while working closely with Data, AI, Cybersecurity, Enterprise Architecture, Infrastructure, PMO, and IT Compliance to ensure solutions are scalable, compliant, secure, and aligned to enterprise standards. A key part of this role will be helping Commercial and Medical Affairs use technology, data, automation, and AI to scale more effectively. Commercial and Medical Affairs are both high-value, high-complexity areas where technology decisions directly affect business execution, customer engagement, patient access, field productivity, insight generation, and compliance. This leader will partner with business leaders to anticipate how evolving strategies, operating models, field needs, data requirements, and global growth affect the technology roadmap, and translate those needs into practical, durable technology plans. Key Responsibilities Commercial and Medical Affairs IT Strategy & Executive Partnership Serve as the senior IT business partner for Madrigal’s Commercial and Medical Affairs organizations, building trusted relationships with the respective ELT members and their leadership teams. Translate Commercial and Medical Affairs business strategies into multi-year technology roadmaps, investment priorities, and portfolio plans. Provide strategic technology guidance across Commercial and Medical Affairs capabilities, including sales, marketing, market access, patient services, commercial operations, sales operations, forecasting, insights and analytics, incentive compensation, training, digital, omnichannel, medical information, medical communications, publications, field medical, medical operations, grants, investigator-initiated trials, KOL engagement, congresses, and related business capabilities. Partner with business leaders to identify opportunities where technology, data, automation, and AI can improve speed, effectiveness, customer engagement, patient access, field productivity, compliance, visibility, and decision-making. Represent Commercial and Medical Affairs needs within ITLT and enterprise governance forums, ensuring business priorities are visible, well-understood, and appropriately sequenced. Navigate competing priorities across Commercial and Medical Affairs, facilitating balanced recommendations that align with enterprise and corporate objectives. Ensure global Commercial and Medical Affairs technology needs are represented in enterprise planning, while recognizing that the U.S. business is the primary near-term driver of scale and complexity. Portfolio, Roadmap & Investment Leadership Own the Commercial and Medical Affairs IT portfolio globally, including roadmap development, investment planning, prioritization, and value realization. Partner with PMO and IT leadership to ensure initiatives are appropriately scoped, sequenced, resourced, governed, and delivered. Develop clear business cases for technology investments, including expected value, risk, implementation approach, resource needs, and long-term operating implications. Make start / stop / sequence recommendations for Commercial and Medical Affairs IT initiatives based on business value, risk, capacity, dependencies, and strategic alignment. Ensure Commercial and Medical Affairs IT roadmaps are realistic, integrated, and aligned with enterprise architecture, data strategy, cybersecurity, infrastructure, and compliance expectations. Provide executive-level visibility into portfolio health, delivery risks, resource constraints, and key decisions needed to keep work moving. Ensure technology investments support scalable commercial growth, medical engagement, patient access, global expansion, lifecycle execution, and business value realization. Commercial Technology Leadership Lead IT partnership and delivery for Commercial functions, including Sales, Marketing, Market Access, Patient Services, Commercial Operations, Sales Operations, Forecasting, Insights and Analytics, Incentive Compensation, Training, Digital, Omnichannel, and related commercial capabilities. Support the continued optimization and scaling of Madrigal’s Commercial technology landscape, including systems and capabilities that enable field execution, customer engagement, patient access, payer engagement, market insight, commercial operations, and decision-making. Partner with Commercial leaders to identify technology needs across the commercial lifecycle and translate those needs into practical, scalable solutions. Provide leadership across Commercial platforms and capabilities such as CRM, data warehouse / data lake capabilities, marketing automation, consent management, MDM, territory alignment, call planning, field reporting, speaker programs, sample management, patient services platforms, and related commercial systems. Ensure Commercial technology investments support field effectiveness, omnichannel engagement, patient identification, market access execution, patient services operations, commercial analytics, and business agility. Work closely with Data & AI to ensure Commercial data needs are represented in Madrigal’s broader enterprise data strategy, including HCP, HCO, patient, payer, claims, specialty pharmacy, CRM activity, consent, digital engagement, market access, and patient access data. Identify opportunities to improve visibility, process consistency, data quality, productivity, and decision-making across Commercial teams and external partners. Medical Affairs Technology Leadership Lead IT partnership and delivery for Medical Affairs functions, including MSLs, Medical Information, Medical Communications, Publications, Field Medical, Medical Operations, Grants, Investigator-Initiated Trials, KOL Engagement, Congresses, and related medical capabilities. Support the continued advancement of Madrigal’s Medical Affairs technology landscape, with a focus on scaling advanced capabilities, improving insight generation, enabling field medical excellence, and supporting compliant medical engagement. Partner with Medical Affairs leaders to identify technology needs across the medical lifecycle and translate those needs into practical, scalable solutions. Provide leadership across Medical Affairs platforms and capabilities such as Veeva CRM, Medical Information, inquiry management, publication planning, grants / IIT systems, KOL management, medical content, field medical insights, congress planning, and related medical systems. Ensure Medical Affairs technology investments support medical engagement, scientific exchange, insight capture, medical content, inquiry response, publications, evidence generation, and operational excellence. Partner closely with Data & AI to identify and enable high-value AI use cases across Medical Affairs, including field medical insights, MSL insight synthesis, medical inquiry support, content intelligence, KOL engagement, and other future-state capabilities. Ensure Medical Affairs technology aligns appropriately with Commercial platforms where shared capabilities create value, while maintaining the controls, governance, and separation needed for compliant medical and commercial operations. Capability Building, Service Delivery & Business Outcomes Lead the Commercial and Medical Affairs IT Business Partnership organization and ensure it can scale with the evolving needs of Commercial and Medical Affairs. Own the Commercial and Medical Affairs IT application portfolio globally, including lifecycle management, roadmap alignment, enhancement planning, operational support, and continuous improvement. Establish a clear service delivery model for Commercial and Medical Affairs IT, including support expectations, ownership, escalation paths, vendor responsibilities, performance management, and business continuity. Ensure Commercial and Medical Affairs applications are stable, compliant, well-supported, and continuously improved to meet business, regulatory, privacy, compliance, and operational needs. Maintain executive accountability for technology outcomes across the Commercial and Medical Affairs portfolio, including delivery performance, adoption, value realization, operational readiness, and risk management. Ensure delivery teams, managed service providers, and strategic partners understand business objectives, success measures, compliance expectations, and operating requirements. Manage vendors and external partners supporting the Commercial and Medical Affairs IT portfolio, ensuring accountability for service quality, delivery outcomes, and long-term supportability. Ensure Commercial and Medical Affairs IT initiatives follow appropriate controls for privacy, consent, promotional review, MLR, pharmacovigilance intake, adverse event reporting, Sunshine / transparency reporting, data use rights, cybersecurity, audit readiness, and other applicable compliance expectations. Build the right mix of business partnership, product ownership, application management, vendor oversight, compliance awareness, data fluency, AI enablement, and delivery leadership within the Commercial and Medical Affairs IT team. Drive continuous improvement in how IT engages with Commercial and Medical Affairs, moving from reactive support to proactive strategic partnership. Create a culture of ownership, service, accountability, and practical problem-solving across the Commercial and Medical Affairs IT organization. Ensure technology decisions support Madrigal’s ability to scale globally, operate compliantly, improve patient access, strengthen customer and medical engagement, and deliver for patients. Qualifications Education Bachelor’s degree in Computer Science, Information Systems, Engineering, Life Sciences, Business, or a related field required. Advanced degree, such as an MBA, MS, or related graduate degree, preferred. Equivalent combination of education and relevant experience may be considered. Experience Typically requires 20+ years of progressive experience in IT, digital, technology strategy, business partnership, enterprise applications, commercial technology, medical technology, or related technology leadership roles. Significant experience in biotech, pharmaceutical, life sciences, or other regulated healthcare environments required. Demonstrated experience partnering with senior executives or functional leadership teams to translate business strategy into technology roadmaps and investment plans. Strong understanding of Commercial and / or Medical Affairs business processes, systems, data needs, compliance requirements, and operating models. Experience leading technology portfolios across complex, cross-functional, global environments. Experience managing teams, budgets, vendors, strategic partners, and multi-year technology roadmaps. Experience supporting commercial-stage life sciences organizations, including field force effectiveness, omnichannel engagement, market access, patient services, commercial operations, medical engagement, and related capabilities. Experience with relevant life sciences platforms and capabilities across CRM, Veeva, Salesforce, marketing automation, patient services, MDM, consent, commercial data, medical information, medical content, publications, grants / IITs, KOL engagement, field medical insights, data, integrations, and enterprise systems. Experience operating in regulated environments with working knowledge of commercial and medical compliance considerations, including promotional review, MLR, privacy, consent, pharmacovigilance intake, adverse event reporting, Sunshine / transparency reporting, medical / commercial separation, data use rights, audit readiness, and compliance-by-design practices. Experience enabling data, analytics, automation, and AI use cases in Commercial and / or Medical Affairs environments preferred. Prior experience in a high-growth biotech or mid-sized pharma environment preferred. Skills and Competencies Executive presence and credibility with senior business and IT leaders. Ability to influence ELT-level stakeholders and resolve competing priorities across functions. Strong strategic thinking, with the ability to connect corporate objectives, functional strategy, and technology execution. Practical operating judgment; able to build structure without unnecessary bureaucracy. Strong portfolio and investment discipline, including prioritization, sequencing, value realization, and risk management. Ability to lead through ambiguity and scale technology capabilities in a growing commercial-stage organization. Strong understanding of regulated life sciences commercial and medical operations and the role technology plays in enabling compliant growth. Ability to develop talent, build teams, and create durable internal capability across business partnership, application management, service delivery, vendor management, and portfolio leadership. Strong collaboration style, with the ability to work across Enterprise Architecture, Data, AI, Cybersecurity, Infrastructure, PMO, IT Compliance, and business functions. Strong comfort with AI-enabled business transformation, including the ability to help Commercial and Medical Affairs leaders identify, prioritize, govern, and adopt high-value AI use cases. Clear communicator who can translate complex technology topics into business-relevant options, trade-offs, and recommendations. *Hybrid work schedule - 3 days a week working in office* Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $294,722 - $360, 215 per year. We comply with all applicable minimum wage laws. All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected]. Join our growing team focused on transforming the treatment of people with liver diseases. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

VP, Commercial & Medical Affairs IT Business Partner.

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