Senior Scientist, Imaging Duration: 12 months Location: Hamilton, ON Onsite 5 days/ week Description: Fusion Pharmaceuticals, part of the AstraZeneca Group, is redefining precision oncology with next‑generation radio conjugates that deliver powerful alpha‑emitting payloads directly to tumors. Our pipeline spans multiple first‑in‑class programs—backed by a GMP‑compliant, brand new radiopharmaceutical facility in Hamilton, we’re turning groundbreaking science into real‑world impact for patients. Join us at the forefront of radio pharma innovation and be part of turning breakthrough science into meaningful outcomes for patients—come build what’s next with us! The Role: As Sr. Scientist, Imaging, this role is for an experienced preclinical imaging scientist to join the In Vivo Pharmacology team within AstraZeneca’s Radioconjugate Discovery Group. The successful candidate will provide strategic and technical expertise in the conception, design, execution and interpretation of preclinical imaging studies. A critical component will be the integration of nuclear imaging methodologies with pharmacology and ex vivo readouts to provide decision-enabling insights across Discovery activities including candidate screening and selection, mechanism of action, dosimetry, and biomarker discovery. What you’ll do Design, conduct, and analyze imaging-based biodistribution and mechanistic studies of radiopharmaceuticals in rodent models of cancer (or other disease indications of interest) to enable decision-making data packages for go/no-go decisions. Perform reconstruction and quantification of multimodal imaging data Drive the development and implementation of imaging-based methods to explore dosimetry and PK/PD relationships as they relate to mechanism of action across our therapeutic pipeline. Integrate results with ex vivo tissue biodistribution and efficacy studies Build strong partnerships with cross-functional experts, align collaborators and clearly communicate plans and results to teams and governance Develop and expand internal preclinical imaging capabilities and spearhead the incorporation of nuclear imaging modalities into AstraZeneca’s Radioconjugate Discovery experimental workflow. Align nuclear medicine imaging protocols, including review of parameters for QC, image acquisition and reconstruction, radiation dose determination, and protocol dose management Oversee the maintenance, calibration, and operation of innovative PET/SPECT/CT/MRI/Optical imaging equipment Mentor and train junior scientists on image acquisition, reconstruction, and analysis Produce high quality and well documented data with strong attention to detail Contribute to internal project teams through the setting and achievement of scientific goals, communication of results, and solving multifaceted scientific challenges Other duties as required Essential for the role MSc or Ph. D (Biochemistry, Biology, Immunology, Biomedical Engineering, Medical physics, Molecular/Cell Biology or related field) 3–6+ years of hands-on preclinical in vivo imaging in mouse models, demonstrating expertise in PET/SPECT and at least one of MRI or CT Experience with in vivo mouse solid tumor models including IV injections, tumor implantation and tissue collections Proficiency with analysis tools (PMOD, VivoQuant, 3D Slicer, Amide) and scripting (Python/MATLAB/R) for automation and reproducibility Expertise with the operation of nuclear imaging equipment including software image reconstruction, analysis, and quantification of nuclear imaging data Ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment Dedicated to finding practical solutions and works well with others in a multi-disciplinary setting, with the ability to communicate with colleagues at all levels Experience with the safe handling of radioactive and biohazardous materials Desirable for the role Theranostic strategy experience and preclinical dosimetry modeling Proficiency in quantitative image analysis and statistics and integration with ex vivo and PK/PD datasets Experience evaluating radioconjugates in solid tumors (antibody-, peptide-, or small-molecule–based), including isotope/chelator selection and labeling parameters impacting in vivo behavior. Biotech or pharmaceutical experience is an asset Great People want to Work with us! Find out why: GTAA Top Employer Award for 11 years Top 100 Employers Award Canada’s Most Admired Corporate Culture Learn more about working with us in Canada View our YouTube channel Are you interested in working at AZ, apply today! AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing [email protected]. ⠀ Annual base salary for this position ranges from 108,713.60 to 142,686.60. AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs. In some cases, offers outside the range may also be considered to address unique circumstances. In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role). Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks’ paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program. We are using AI as part of the recruitment process. This advertisement relates to a current vacancy. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

Senior Scientist, Imaging (12 Month Contract).

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