Position Overview:
Our Eurofins PSS team is seeking an Upstream Scientist to work onsite supporting our client's upstream process development activities related to the production of sterile, injectable lentiviral vector (LVV)-based gene therapy products. The successful candidate will help support the execution and optimization of LVV production protocols, maintenance of mammalian suspension cell culture systems, process robustness, and yield-improvement studies. This role partners closely with cross-functional teams across the CMC project teams to support all upstream operations for the client's program. This is an excellent opportunity for a detail-oriented scientist to contribute directly to the development of novel gene therapy products from an established, hands-on upstream role.
Job Responsibilities:
- Execute LVV production protocols using shake flasks and benchtop bioreactors to support ongoing process development and characterization studies.
- Support routine maintenance of suspension cell cultures, applying strong aseptic technique and sterile workflow practices to preserve culture health and integrity.
- Collaborate with cross-functional teams to coordinate analytical testing, exchange materials, share technical observations, and align on project timelines.
- Maintain lab stocks, supplies, and equipment specific to the upstream team to support daily operations.
- Document process data in electronic lab notebook and shared databases and communicate key observations in team meetings.
Basic Minimum Qualifications:
- B.S. in Biology, Biochemistry, Biological Engineering or a related field with at least 1 year of relevant industry experience OR M.S. in Biology, Biochemistry, Biological Engineering or a related field with at least 6 months of relevant industry experience.
- Proficient in mammalian suspension cell culture operations, including execution of established production protocols for routine culture maintenance and shake flask seed train expansion.
- Strong aseptic technique, with hands-on experience working within a biosafety cabinet (BSC) to maintain sterile, contamination-free workflows.
- Experience with buffer and media preparation to support ongoing cell culture operations.
- Experience documenting process results in electronic lab notebooks and effectively communicating experimental observations to management and cross-functional team.
- Meticulous attention to detail in sample tracking, experiment execution, data recording, and laboratory documentation.
- Ability to set priorities and multi-task activities to effectively manage workflows and drive deliverables to completion.
- Strong team orientation, with excellent organizational skills, self-motivation, and a positive attitude.
- Strong communication skills, with the ability to clearly communicate experimental results and observations.
- Authorization to work in the United States indefinitely without restriction or sponsorship.
Preferred Qualifications:
- Previous experience with viral vector, cell therapy, gene therapy, or related biologics process development.
- Hands-on experience operating and maintaining laboratory equipment, including shake flasks, benchtop bioreactor systems, peristaltic pumps, and tube welders.
- Experience performing cell banking activities to support consistent, well-characterized starting material for upstream production.
- Familiar with gene delivery techniques such as transient transfection.
This role is a full-time, permanent position Monday-Friday 8am-5pm with occasional weekend/holiday work, as well as periodic work outside of working hours. . Candidates currently located within commutable distance to Boston, MA are encouraged to apply.
Excellent full-time benefits include:
- Comprehensive medical coverage, dental, and vision options
- Life and disability insurance
- 401(k) with company match
- Paid vacation and holidays
- Eligibility for yearly goal-based bonus & merit-based increases
- Compensation: $32.00-$36.00 per hour based on education and relatable industry experience.
Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.