Location ST. LOUIS, MO 63108 Scheduled Hours 40 Position Summary Provides critically complex research and experimentation for department/s allowing the advancement of scientific analysis and discovery. Serves as a subject matter expert offering support, training and guidance relative to the discipline/area. May participate and/or present on the research developed, or the established work of those within the department. The Pottier Laboratory in the Department of Neurology at Washington University School of Medicine is recruiting a Bioinformatician to join our research on the genetics and transcriptomics of Alzheimer disease, frontotemporal dementia and related neurodegenerative disorders. The position focuses on single-nuclei RNA sequencing (snRNA-seq) of human brain, with additional work in whole-genome sequencing (short- and long-read). You will work closely with the PI, postdocs, other computational scientists and clinical and neuropathology collaborators as part of the NeuroGenomics and Informatics (NGI) Center, a group of more than 20 computational and statistical researchers. Job Description Primary Duties & Responsibilities: Implements: Algorithms and computer software for analyzing omics-based data sets [high-throughput, massively parallel genomic/proteomic/clinical]; Data management and analysis solutions that aid in the storage, investigation and dissemination of large data sets. Coordinates research project with other investigators and institutions. Participates in developing hypotheses and experimental design. Assists with reporting of methods, data and results. Process and analyze short- and long-read snRNA-seq data, including QC, clustering, cell-type annotation, differential expression and isoform-level analyses. Process and analyze short- and long-read WGS data, including QC, variant calling, structural variants and association analyses. Integrate transcriptomic and genetic data with clinical, neuropathological and proteomic data. Develop, maintain and improve reproducible pipelines on high-performance computing systems as data and tools change. Organize, back up and share data with collaborators and consortia. Advise team members and train and supervise junior scientists. Participate in lab and collaborator meetings. Contribute to manuscripts, grants and reports, including methods, results and figures. Working Conditions: Job Location/Working Conditions Works in a laboratory environment with potential exposure to biological and chemical hazards Must be physically able to wear protective equipment and to provide standard care to research animals Normal office environment. Physical Effort Typically sitting at desk or table. Repetitive wrist, hand or finger movement (PC Typing). Equipment Office equipment. The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time. Required Qualifications Education: Bachelor’s degree or combination of education and/or experience may substitute for minimum education. Certifications/Professional Licenses: No specific certification/professional license is required for this position. Work Experience: Relevant Experience (2 Years) Skills: Not Applicable Driver's License: A driver's license is not required for this position. More About This Job WashU seeks highly motivated individuals who are able to perform duties in a manner consistent with our core mission and guiding principles. Preferred Qualifications Education: Master's degree Certifications/Professional Licenses: No additional certification/professional licenses unless stated elsewhere in the job posting. Work Experience: No additional work experience unless stated elsewhere in the job posting. Skills: Analytical Thinking, Bioinformatics Tools, Communication, Complex Data Analysis, Computational Biology, Critical Reasoning, Gene Expression Microarray, Genome Sequencing, Group Problem Solving, Human Genetics, Model Organism Grade R09 Salary Range $41,700.00 - $75,600.00 / Annually The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget. Questions For frequently asked questions about the application process, please refer to our External Applicant FAQ. Accommodation If you are unable to use our online application system and would like an accommodation, please email [email protected] or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits Statement Personal Up to 22 days of vacation, 10 recognized holidays, and sick time. Competitive health insurance packages with priority appointments and lower copays/coinsurance. Take advantage of our free Metro transit U-Pass for eligible employees. WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%. Wellness Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more! Family We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? We’ve got you covered. WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us. For policies, detailed benefits, and eligibility, please visit: https://hr.wustl.edu/benefits/ EEO Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity or shared ancestry, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. As a federal contractor, the university maintains affirmative action programs to implement its equal employment opportunity policy for individuals with disabilities and protected veterans, in accordance with Section 503 of the Rehabilitation Act of 1973, as amended, and the Vietnam Era Veterans’ Readjustment Assistance Act of 1974 (VEVRAA), as amended. Q: Can I create a job alert to notify me when jobs of interest are posted? A: Yes! After you create a Candidate Home account, you can set up and manage job alerts to be sent to you either daily or weekly, according to the filters you select. You can add, edit, or delete job alerts at any time. You will need to opt in to communications from WashU when you set up your first alert and will only receive alerts for jobs posted after the alert has been created. Set alerts today so you do not miss any new opportunities! Washington University in St. Louis' collective success is significantly attributed to the passion and outstanding efforts of our community. Our staff, faculty and trainees are committed to excellence and dedicated to carrying out our missions of research, teaching and patient care. WashU prides itself on being a place where people matter, and serious work is done. Our people work together in an inclusive community that celebrates diverse perspectives, collaboration and innovation. We are a community of individuals inspired to work together to develop big ideas and tackle challenging problems. We value the well-being of our people. WashU strives to create a positive employee experience where staff, faculty and trainees thrive, both personally and professionally. Our employees find meaning, connection and vitality in their work and life with a healthy work-life balance and support to learn, grow and make an impact at WashU, the community and the world. Useful Links Who We Are Human Resources Benefits Living in St. Louis Frequently Asked Questions Accommodation If you are unable to use our online application system and would like an accommodation, please email [email protected] or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. Regulatory Postings Know Your Rights: Workplace Discrimination is Illegal Poster (English; Spanish)

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