About Stylus Medicine:
Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.
About the Role:
Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team and build automation capabilities that accelerate the development of our next-generation gene editing tools. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. This individual will play a key role in discovery and engineering efforts, advancing recombinase-based genome editing platforms and collaborating across diverse R&D teams.
Key Responsibilities & Accountabilities:
- Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows
- Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT)
- Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products
- Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens
- Coordinate DNA synthesis and reagent orders with external vendors
- Manage raw material, plasmid, and RNA inventories
- Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks
- Present findings clearly to other teams and contribute to scientific discussions and decision-making
Qualifications & Skills:
- BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field
- Experience with automated liquid handling systems (e.g., Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting
- Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus
- Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
- Hands-on molecular biology experience, including cloning and RNA production and purification
- Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling
- Experience with laboratory inventory management
- Track record of generating precise, reproducible data and performing rigorous quantitative analysis
- Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences
- Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects
- Strategic thinker who effectively plans and prioritizes to maximize scientific impact
- Collaborative mindset with a team-first attitude
- Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty
Pay Range: $105,000 - $120,000