Job Description General Summary: The Executive Director, Marketing / Head of Marketing, Endocrinology is responsible for defining and leading Vertex’s endocrinology marketing strategy across multiple assets. This role develops a deep understanding of the treatment landscape, customer and patient needs, and Vertex’s position in the market; sets strategic and performance goals; and leads execution across the portfolio. As a people manager, the Executive Director is accountable for the marketing budget and for building, developing, and leading a high-performing team. Key Duties and Responsibilities: Define the endocrinology marketing strategy and oversee brand planning, launch readiness, and lifecycle activities, as applicable. Lead the development and execution of strategic and tactical plans for healthcare professionals and other relevant audiences. Oversee the creation of external promotional materials and communications in partnership with appropriate cross-functional review teams. Develop short- and long-term forecasting assumptions informed by market dynamics and business drivers. Generate and synthesize insights from healthcare professionals, patients, caregivers, market research, and advisory boards to identify opportunities and inform decisions. Partner with Medical Affairs, Market Access, Sales, Commercial Operations, and other functions to align plans and support business goals. Establish performance measures, monitor results, evaluate return on investment, and adjust plans and resources accordingly. Lead, coach, and develop marketing team members; foster collaboration, accountability, and professional growth. Knowledge and Skills: Demonstrated ability to define strategy for a complex pharmaceutical brand or portfolio. Ability to translate customer, patient, and market insights into actionable marketing plans. Strong analytical and strategic judgment, including experience with performance measurement, forecasting, resource allocation, and return-on-investment assessment. Understanding of the relationship between market dynamics, business drivers, and revenue. Experience leading cross-functional work and developing external pharmaceutical communications. Strong people leadership skills, including coaching, performance management, and career development. Proficiency with Microsoft PowerPoint, Excel, and Word. Endocrinology experience is preferred. Education and Experience: Bachelor’s degree in marketing, business, a scientific discipline, or a related field required. Typically requires 12 years of relevant work experience, including 5 years of management or supervisory experience, or an equivalent combination of education and experience. Extensive experience in pharmaceutical marketing or a closely related field, such as pharmaceutical sales or agency marketing. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

Executive Director, Head of Marketing, Endocrinology.

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