Job Description Position Summary: The Director of Portfolio and Program Management (PPM) sits within the COO organization and provides strategic and operational leadership across a portfolio of cross-functional Research programs and projects, spanning early research through candidate preclinical development. The role is accountable for both portfolio-level oversight and direct program management, ensuring alignment with research priorities and delivery against organizational objectives. Working in close partnership with the Cell and Gene Therapies (CGT) Site Head, Chief of Staff, Program Leaders, and cross-functional stakeholders, the Director provides integrated portfolio insights, enables prioritization, drives strategic decision-making, and ensures execution of critical site and program objectives. As a key leader within Research PPM, the Director promotes high-performing, data-driven ways of working, strengthens portfolio governance and visibility, and serves as a trusted thought partner to research leadership. The role also includes line management responsibilities and contributes to the development of PPM capabilities, talent, and organizational effectiveness. Key Duties and Responsibilities: Partner with Program Leaders to lead portfolio planning, drive strategic decision-making, and ensure effective execution across research and early development programs. Lead and oversee a portfolio of Research programs and projects from early research through candidate preclinical development, ensuring alignment to organizational and corporate priorities. Directly lead priority cross-functional projects and programs, driving planning, execution, decision-making, and delivery against key milestones and goals. Partner closely with the CGT Site Head and Chief of Staff to provide clear, accurate, and timely portfolio and program updates, including status, risks, milestones, resource needs, and decision points, while helping ensure delivery of site objectives. Guide cross-functional R&D teams to establish high-performing, data-driven ways of working that deliver on corporate objectives and priorities. Lead the approach for cross-functional decision-making and issue resolution, identifying key stakeholders and driving alignment on priorities, governance, and actions. Develop and maintain integrated portfolio and project timelines and reporting, defining critical path activities, interdependencies, and potential bottlenecks. Proactively identify, assess, mitigate, and escalate risks, gaps, challenges, and roadblocks that could impact program or site delivery. Lead the generation of program assumptions for annual resource allocation and budgeting across Research and Development functions. Identify, communicate, and manage resource constraints, synergies, and redundancies across the portfolio. Effectively manage key meetings, stakeholder communications, action items, decisions, and follow-through to support execution and accountability. Communicate complex topics to stakeholders through effective storytelling and content creation. Establish team operating norms and identify opportunities to improve team and portfolio performance. Work with Portfolio and Program leadership to build, manage, coach, and retain PM staff. Serve as a key PPM leader, translating site goals into actionable portfolio and project plans. Knowledge and Skills: Demonstrated ability to lead a portfolio of complex projects in a fast-paced Research environment. Strong ability to partner with senior site leadership to translate strategic priorities into executable plans. Proven ability to drive accountability and delivery across matrixed cross-functional teams. Comprehensive knowledge of project and portfolio management principles, best practices, tools, technology and methods. Leadership experience managing cross-functional teams. Excellent written and oral communication skills, including well-developed presentation skills. Comprehensive pharmaceutical drug discovery and development knowledge across multiple disciplines. Exceptional organizational skills and an ability to manage multiple priorities. Strong collaboration skills to effectively interact with internal or external stakeholders at all levels of the organization. Ability to work in a fast-paced and collaborative environment and manage multiple concurrent projects with a high degree of independence. Experience in carrying out Risk Analysis, Decision Analysis and Contingency Planning. A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society. Ability to embody the Vertex Core Values of Uncompromising Commitment to Patients, Fearless Pursuit of Excellence, Innovation is Our Lifeblood, and “We” Wins. Education and Experience: Typically requires an advanced degree in Life Sciences or a relevant field, (PhD degree preferred or strong demonstration of equivalent combination of relevant educational and professional training). Typically requires 10 years of experience, or the equivalent combination of education and experience. Typically requires significant experience in portfolio and program management within drug discovery and/or early development, including leadership of cross-functional teams and complex project portfolios. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $162,200 - $243,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

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2 Nov, 2026

Vrtx

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