Job Description General Summary: The Pain Territory Business Manager (TBM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor of NaV1.8 in acute pain. The TBM reports into a Regional Field Leader and serves as a field representative for JOURNAVX within the community setting. The TBM will work closely with Pain Territory Account Managers (PTAMs) who are also field-based reps within the geographic area who serve as account managers within hospitals/health systems and are responsible for driving and pulling through hospitals/health system volume and access as well as targeted physicians within their hospital networks. Key Responsibilities: Establishes meaningful and professional relationships with assigned physicians with the goal of building awareness and driving adoption of JOURNAVX. Develops and maintains expertise on the product’s clinical attributes and patient unmet need and educates healthcare professionals on product use in appropriate patients. Develops a deep understanding of assigned physicians, territory & market dynamics, stakeholder mapping, key decision maker relationship management, patient protocols, referral network navigation, access, and drivers & barriers. Implements and maintains strategic territory business plans that identify and harness business opportunities and patient-focused solutions for significant growth across the customer landscape while supporting the PTAM led account engagement strategy within hospital settings. Drives sales performance and ensures forecasts and assigned budgets meet or exceed territory expectations. Collaborates compliantly with other field team members (e.g., PTAMs, field medical, HEOR, IDN and Payer Account teams) and headquarter colleagues to create aligned business plans, focus on strategic drivers, share best practices, and inform initiatives. Role models ethics and integrity in the work that you do to support our culture of compliance and earn trust with external stakeholders, particularly in the context of this market and its history. Required Experience and Knowledge/Skills: 5+ experience in biotech sales; product launch experience is highly desired Product launch experience in acute pain and successfully engaging with diverse physicians is highly desired. Experience effectively engaging with retail pharmacies to ensure stocking and managed care pull through. Experience with pulling through the implementation of inpatient formularies, protocols, pathways, and order sets. Ability to understand the nuances of patient treatment in the geography, including but not limited to care coordination, patient referral patterns, and influence networks. Highly competent in a multitude of IT capabilities to support the business needs including Veeva CRM. Experience working in a highly matrixed environment. Bachelor’s degree Other Requirements Employee will be required to establish certain customer credentials and requirements, which include, but may not be limited to, successful completion of trainings, background screens, drug testing and vaccinations. Must live and work within the territory. Depending on the territory’s geography and work requirements may also be required to live within a reasonable distance to a major airport. Valid driver’s license and in good standing. Travel by car or airplane up to 80% of the time and work after hours as required by business needs. 10-30% of overnight travel may be required depending on territory. Pay Range: $140,000 - $160,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an incentive bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $120,000 - $180,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected] Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

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