What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. We are seeking an experienced Software Test Engineer II to support the instrument manufacturing and NPI (new product introduction) development of software for Illumina’s sequencing instruments. This role combines hands-on system testing, technical problem-solving, and close collaboration with cross-functional teams to help ensure the quality and reliability of our next-generation sequencing platforms. The ideal candidate thrives in a multidisciplinary environment and brings curiosity, sound technical judgment, and a quality-first mindset to their work. This is primarily a manufacturing floor support engineer as well as a hands-on, system-level software testing role involving physical sequencing instruments, on-market & future NPI. The role emphasizes test design, exploratory testing, execution, troubleshooting, communicating and collaborating. Coding and test automation skills are valuable but are not the primary focus of the position. Responsibilities: Manufacturing floor support and troubleshoot software, server, cybersecurity, and system-level issues in production and NPI prototype development, evaluating manufacturing Non Conformances Create and implement ECO changes to product and manufacturing processes and system configurations Lead projects to resolve trending issues in manufacturing and the field Work with cross functional teams (Quality, Manufacturing, Development, Regulatory, Supply Chain) to achieve Instrument Manufacturing Operation Goals while maintaining Compliance and security requirements Develop test strategies, plans, and test cases from product, system, and software requirements. Execute functional, integration, system, and regression tests for software features, server applications, and integrations on DNA sequencing instruments. Perform exploratory testing to identify defects, unexpected behaviors, usability concerns, and system-level risks. Own software verification activities for assigned features or subsystems, including planning, execution, defect reporting, and results documentation. Collaborate with cross-functional stakeholders to ensure software solutions meet user and system needs. Investigate defects and perform root-cause analysis in collaboration with software, firmware, hardware, manufacturing, and systems teams. Work within established software development, quality, and requirements management processes for regulated products. Participate in requirements, design, and planning activities to identify risks, improve testability, and strengthen verification strategy. Use approved AI-assisted tools to improve test design, exploratory testing, failure analysis, documentation, and workflow efficiency while applying appropriate human review and complying with data privacy, security, and regulated-product quality requirements. The responsibilities listed above are essential but not exhaustive. Individual responsibilities may change based on business needs. Requirements: Bachelor’s degree in Computer Science, Software Engineering, or a related technical field. 3+ years of professional experience working in software test, software quality, software systems integration, or a related role. Experience with functional, integration, system, and regression testing. Experience independently owning feature-level or subsystem-level software verification activities. Strong troubleshooting and analytical skills, including the ability to isolate failures across software, firmware, hardware, and system boundaries. Familiarity with defect tracking and requirements management platforms such as Jira and Jama. Ability to work regularly with physical instruments in a laboratory environment. Familiarity with Linux and Windows OS environments and command-line tools. Familiarity with data management and processing via server, single-board compute or compute engines Familiarity with production and customer network/IT setup & different configurations that may impact installation or manufacturing processes Strong written and verbal communication skills, with a willingness to learn from and share knowledge with others. Nice to Have: Familiarity with embedded systems, communication protocols, or integrating software with hardware modules. Has experience developing/executing simple and complex test automation protocols Cybersecurity regulation knowledge and best practices Familiarity working in a regulated environment, such as medical devices. Experience using AI-assisted engineering tools to support software testing, troubleshooting, test documentation, or analysis. Demonstrates basic scripting or automation experience, such as Python or shell scripting. Project management skills. Gantt chart timeline and critical path calculations, risk assessment experience, software agile experience as a scrum lead Has led technical triaging of issues based on level of effort, frequency, and severity Understands process for developing software requirements All listed requirements are considered essential functions of the position. Reasonable accommodations may be provided to enable qualified individuals to perform these functions. Responsibilities may change based on business needs. The estimated base salary range for the Software Test Engineer 2 role based in the United States of America is: $103,000 - $154,600. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long‑term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off. We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact [email protected]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship. The potential of genomics to change the world is unparalleled. At Illumina, we are leading the way. Our technology empowers researchers and clinicians globally to improve cancer treatments, change the course of diseases, protect the environment, and fight food insecurity. We are made up of dedicated professionals, all-in on creating a better world – and we need every skill set on our path to making genomics useful for all. Learn more about life at Illumina. Illumina has been made aware of fraudulent schemes in which individuals falsely claim to represent Illumina, our Talent Acquisition team, or our Human Resources organization. Please note: • All legitimate Illumina career opportunities are posted on the Illumina Careers website. • Illumina will never ask candidates to pay fees, transfer money, purchase equipment, or provide banking information during the recruitment process. • Illumina does not extend employment offers without a formal interview process. • Official recruiting communications will come from authorized Illumina email addresses ([email protected]). If you are unsure whether a communication is legitimate, please contact us at [email protected] before sharing any personal information. Thank you for helping us protect the integrity of the hiring process and your experience.

Software Test Engineer 2.

more at illumina.com.

Senior Director, IT – Global Service, Support & Laboratory Operations

Manufacturing Technician 3

Scientist 1

similar roles.

QA Automation Engineer (Banking)

Battery Test Engineer - Aeromechanical

Senior Supplier Quality Engineer – Structural

Quality Engineer Projects

Manager - QA Investigation and CAPA

Intern - R&D Test Engineer - Spring or Summer 2027