This is an in-office role based in Barcelona, ES, with a requirement to work a minimum of three days per week on-site. Remote or travel flexibility is not available. About AstraZeneca and AISI At AstraZeneca, technology and science meet to change what is possible for patients. We are building a connected, end-to-end Enterprise AI engine that unites data foundations, AI technology, process reinvention, and business-facing AI to accelerate results across the whole value chain. Success depends on being an exceptional connector: you will leverage existing capabilities, promote reuse, share breakthrough ideas across geographies and functions, and focus on scaling impact rather than building in isolation. AI Science & Innovation (AISI) sits at the center of AstraZeneca's R&D AI transformation. Our remit is to build, buy, and deliver the AI models and agents that change pipeline outcomes, across discovery, translational science, biomarkers, and clinical development. Within AISI, the BioPharma Clinical Development AI team is building world-class AI capability to accelerate the design, conduct, and analysis of clinical trials across our BioPharmaceuticals pipeline, in both early and late phase programmes. We partner closely with clinical development, regulatory, and biometrics teams to bring better treatments to patients faster, while adhering to the highest evidentiary standards. The Opportunity Clinical development is one of the most data-rich and decision-intensive parts of bringing a new medicine to patients. Trial design, patient selection, dose optimisation, biomarker strategy, and safety evaluation are all areas where AI and machine learning can add rigour, speed, and precision, as a powerful complement to clinical and statistical expertise. You will work in cross-functional teams across the key BioPharmaceuticals disease areas of cardiovascular, renal, metabolic disease, respiratory, and immunology. Alongside experienced data scientists and clinical collaborators, you will apply modern AI methods to measurably advance the drug pipeline and help build reusable approaches that scale across programmes. Foundation models, agentic systems, and causal AI are advancing rapidly, and the regulatory and methodological frameworks around them are evolving in parallel. In this role you will be hands-on at the frontier, developing, evaluating, and deploying AI methods that directly inform clinical trial design and decision-making. Every model you contribute to will eventually touch a trial that decides whether a patient gets a better therapy. That is the bar we hold ourselves to. What You Will Do Develop and deploy AI/ML methods for clinical trials, including trial design support, dose optimisation, biomarker discovery, digital twins, predictive modelling, and safety and efficacy signal detection. Contribute to end-to-end project delivery, from problem framing and methodology selection through to validation and adoption within study teams, with guidance from senior colleagues on more complex initiatives. Partner with Clinical Development, Biometrics, and Regulatory colleagues to embed AI approaches into study design and decision-making. Build reusable, well-documented data products such as pipelines, packages, and applications, with a software engineering mindset. Apply modern methodologies including foundation models, agentic AI, generative patient models, longitudinal modelling, Bayesian inference, and causal inference, with clear evaluation criteria. Practise data-centric AI and contribute to evaluation and benchmarking frameworks suitable for clinical and regulatory settings. Engage with internal and external scientific communities, contributing to publications and conference presentations. What You Will Bring A degree in a quantitative discipline (e.g. Computer Science, Machine Learning, Statistics, Mathematics, Biomedical Informatics, Computational Biology, Physics, Engineering) at Master's, or PhD level, or equivalent experience. Demonstrated experience in AI/ML method development, shown through delivered models, publications, open-source contributions, or applied projects, ideally in clinical, biomedical, or drug development settings. Hands-on experience with biological or clinical data, such as molecular (DNA, RNA, protein), imaging, or clinical text (EHR, clinical notes). Technical capability in one or more modern AI areas, such as foundation model training and fine-tuning, Bayesian inference, temporal and longitudinal modelling, multimodal integration, model interpretability, or post-training and alignment. Strong Python skills, experience with PyTorch and modern LLM tooling, and familiarity with cloud platforms (e.g. AWS, Azure, GCP). Excellent communication skills, with the ability to translate complex methods into actionable insights for clinical, regulatory, and scientific audiences. Nice To Have Exposure to clinical development, such as trial design, biomarkers, dosing, safety, endpoints, or regulatory processes. Experience with MLOps/LLMOps, uncertainty quantification, or clinical AI benchmarking. Peer-reviewed publications in clinical AI, computational drug development, or machine learning. Why AstraZeneca We are investing boldly in AI and data to become truly data-led, bringing together unexpected teams to solve problems that have never been solved before. We empower scientists to experiment, prototype early, and partner credibly across ML, clinical, biostatistics, and regulatory communities. We value learning agility and technical excellence equally, and your work will directly influence trials that shape whether patients receive better therapies. #EAI Date Posted 29-oct-2026 Closing Date 19-nov-2026 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

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