Introduction to role: Are you ready to steer financial strategy that expands patient access and accelerates sustainable growth across the UK and Ireland? This role places you at the heart of decisions that shape launch readiness, pricing, and access—translating insight into action for medicines that change lives. Reporting to the Head of Finance & Commercial Operations, you will serve as the finance lead for a designated disease area with full P&L responsibility across in-line and pipeline assets. Your analysis, modelling and influence will guide cross-functional teams through strategic choices and investment decisions. Can you see yourself turning complex data into clear direction that helps therapies reach under-served patients sooner? You will work closely with Commercial, Medical, Market Access, GFS, Controlling, EUCAN and Global Finance partners to align priorities and deliver measurable outcomes. This role is office-based in London with a minimum of 60% office attendance; travel is limited, primarily within the UK with occasional international exposure. Accountabilities: Strategic financial leadership and business partnering: - Full P&L ownership for a designated disease area across the UK & Ireland, spanning in-line and pipeline assets, driving revenue, expense and contribution objectives. - Partner disease area leadership to evaluate strategic choices and shape the disease strategic plan, launch readiness and loss-of-exclusivity scenarios. - Lead financial modelling and scenario analysis for pricing, reimbursement and access business cases with Market Access and cross-functional stakeholders, producing robust recommendations. - Represent Finance in senior forums; act as the primary interface between local, EUCAN and Global Finance to align priorities and investment decisions that enable scale and speed. Forecasting, planning & analysis and performance management: - Lead strategic plans, annual budgets and monthly forecasts in line with regional and corporate standards and timelines. - Apply AI and advanced analytics to strengthen forecasting, scenario modelling, variance analysis and performance insights. - Lead business performance reviews with franchise and leadership teams; identify risks and opportunities and drive actions to deliver disease-area goals. - Ensure disciplined OPEX and investment deployment so resources align to strategic priorities and value delivery. - Provide monthly financial reporting and clear commentary to local, EUCAN and International stakeholders, translating analysis into actionable recommendations. Financial governance, controls and capability enablement: - Ensure financial integrity through robust month-end close, accurate reporting and compliance with Alexion accounting policies and internal controls, in close collaboration with GFS and Controlling. - Act as a role model for finance business partnering by building financial acumen across the disease team through coaching, training and day-to-day decision support. - Support the Head of Finance on ad-hoc projects and initiatives to strengthen control, capability and performance. Essential Skills/Experience: - Significant post-qualification experience in finance (FP&A, business partnering or controlling) - Experience working in complex, matrix organisations - Proven track record in financial planning, forecasting and performance management - Strong experience partnering senior stakeholders and influencing decisions - Exposure to regional and global finance environments - Outstanding analytical skills with ability to connect data to business decisions - Strong business partnering and stakeholder influencing skills - AI and advanced analytics fluency with ability to translate insights into action - Proactive, curious and solutions-oriented mindset - Ability to challenge constructively and drive continuous improvement - Pharma/biotech experience, particularly in disease-area or franchise models - Experience supporting pricing, reimbursement and access business cases - Understanding of UK & Ireland healthcare and reimbursement landscape - Experience with financial planning, analytics or visualisation tools Why Alexion: Join a mission-driven team focused on improving the lives of people living with rare and devastating conditions through sharp strategy, disciplined execution and bold collaboration. As Alexion, AstraZeneca Rare Disease, we combine the focus and agility of a rare disease leader with the scale and rigor of a global biopharma. We bring finance, market access, medical and commercial together to unlock new approaches that expand access and deliver value. You’ll be trusted to speak up, challenge constructively and make smarter, data-led decisions. We value kindness alongside ambition and invest in real development opportunities so your work today creates measurable impact for patients tomorrow. Date Posted 30-Oct-2026 Closing Date 13-Nov-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

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