Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Mass General Brigham Department of Anesthesiology at Massachusetts General Hospital is seeking a Postdoctoral Research Fellow to conduct basic research in the function, mechanism, and translational applications of tRNA-derived small RNAs (tDRs) and RNA pseudouridylation in heart disease, chronic kidney disease, and Alzheimer's disease. The ideal person for this position should possess good organizational skills, pay close attention to details, and communicate well. The person must be able to work independently, as well as with a team. Qualifications IMPORTANT – APPLICATION INSTRUCTIONS This is a courtesy posting. Please do not submit your application through the Workday "Apply" button. To be considered for this position, please email your CV and cover letter to Dr. Guoping Li at [email protected] Applications submitted only through Workday will not be forwarded to the hiring manager and may not be reviewed. PRINCIPAL DUTIES AND RESPONSIBILITIES: With supervision and guidance, responsibilities of the Postdoctoral Research Fellow will include: Performs independent and highly specialized experimental procedures Designs and implements modifications of research protocols Troubleshooting problems and instructing colleagues in highly specialized techniques Synthesizes and interprets results Performs advanced data recording and analysis using various software programs and statistical techniques Maintaining organized and detailed records of laboratory experiments in electronic laboratory notebooks Presentation of results at lab meetings and national conferences Preparation and submission of research manuscripts to peer-reviewed journals Assisting with preparation of grant applications Other duties as assigned SKILLS/ABILITIES/COMPETENCIES REQUIRED: A successful candidate will: Work independently under general direction of the Principal Investigator Be motivated, meticulous, organized, and detail-oriented Demonstrate initiative and enthusiasm for learning new techniques Have strong analytical and problem-solving skills Possess strong technical abilities and computer science skills Possess exceptional written and oral communication skills as demonstrated by publications and presentation Possess the ability to make independent and effective decisions in a timely fashion Possess competence in research techniques and methodologies Have excellent interpersonal skills Be a team player who works well with other lab members EDUCATION: PhD or MD required in molecular biology, biochemistry, cell biology, genetics, physiology, pharmacology, biomedical engineering, neuroscience, or a related field. EXPERIENCE: Prior laboratory research experience is required, with evidence of strong scientific productivity including at least one first-author peer-reviewed SCI publication. The laboratory is recruiting two Postdoctoral Research Fellows with complementary expertise. Position 1 (Molecular / RNA Biology) requires a solid background in molecular and cell biology and proficiency in standard molecular techniques; experience with non-coding RNA is preferred, and familiarity with next-generation sequencing (RNA-seq / small RNA-seq) library preparation or bioinformatic analysis, gene editing (CRISPR/Cas), and primary-cell or iPSC culture is a plus. Position 2 (In Vivo / Surgical) requires hands-on in vivo experience, particularly microsurgical skills in rodent models of cardiac or kidney disease (e.g., myocardial infarction, transverse aortic constriction (TAC), ischemia-reperfusion injury; renal ischemia-reperfusion, unilateral ureteral obstruction (UUO), or 5/6 nephrectomy); experience with drug administration (including tail-vein, intrapericardial, renal-capsular, and local delivery), echocardiography or cardiac / renal functional assessment, and tissue harvesting and phenotyping is preferred. Open to highly motivated candidates with a relevant background. The secondary appointment will be at Harvard Medical School. SUPERVISORY RESPONSIBILITY (if applicable): List the number of FTEs supervised. Assistance guiding research technicians and trainees in the lab is expected. Additional Job Details (if applicable) The compensation range for this role is between $71,750 - $81,179. Candidate experience is thoughtfully considered throughout the recruitment process, and those with significant experience may be considered for compensation above the starting range listed, as consistent with organizational guidelines and internal equity Years of experience 0 $71,750 - $73,544 1 $73,544 - $75,382 2 $75,382 - $77,267 3 $77,267 - $79,199 4+ $79,199 - $81,179 Remote Type Onsite Work Location 55 Fruit Street EEO Statement: 1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system. We recognize that increasing value and continuously improving quality are essential to maintaining excellence.

Postdoctoral Research Fellow.

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