Are you interested in applying spectroscopy, chemometrics and process modelling to real-time pharmaceutical manufacturing? This interdisciplinary thesis project will investigate whether NIR and Raman spectroscopy can independently predict all active pharmaceutical ingredients and excipients in a formulation during continuous direct compression. About AstraZeneca: AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world’s most serious diseases. But we’re more than a global leading pharmaceutical company. At AstraZeneca, we're dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit. About the Opportunity: As a Thesis Worker at AstraZeneca, you’ll find an environment that’s full of unique opportunities and exciting challenges. Here, you’ll have the opportunity to pursue your areas of interest whilst equally developing a broad skillset and knowledge base to get the best out of your experience. You’ll be working on meaningful projects to make an impact and deliver real value for our patients and our business. Thesis work description: Real-time monitoring is an important part of advanced pharmaceutical manufacturing. In this project, you will investigate how NIR and/or Raman spectroscopy, together with process information, can provide reliable information about the composition of pharmaceutical formulations. The work combines pharmaceutical manufacturing, spectroscopy, chemometrics and process modelling, using real formulations and PAT data. You will develop and evaluate modelling approaches and investigate the chemical, physical and statistical factors that affect their performance. If possible, selected approaches will be tested on a continuous direct compression platform, with potential for real-time implementation. The project is exploratory, and demonstrating that certain formulation components cannot be independently quantified is considered a valuable scientific outcome. The work will be carried out in close collaboration with scientists experienced in PAT, spectroscopy, pharmaceutical processing and data analysis. Key Objectives: Investigate whether NIR and/or Raman spectroscopy can predict every API and excipient in a pharmaceutical formulation in real time. Assess whether each component is independently identifiable from the available information. Compare individual PLS models (PLS1) with multicomponent models (PLS2). Investigate physically constrained models, including non-negative concentration predictions, formulation mass balance and mechanistic models. Explore hybrid models combining spectroscopy with process information. Design calibration mixtures to separate true spectral information from chance correlations. If possible, test selected approaches dynamically on a continuous direct compression platform. Placement:   This is an on-site position at AstraZeneca Gothenburg. Please note, AstraZeneca does not support with accommodations for this role Structure: Duration: Spring 2027 Credits: 30 Essential Requirements: Enrolled in a Master's programme within analytical chemistry, pharmaceutical science or technology, chemical engineering, engineering physics, applied physics, applied mathematics, chemometrics, data science or related discipline. Fundamental understanding of spectroscopy and the underlying chemical and physical phenomena. Strong interest in multivariate modelling, process modelling, data analysis and automation and experimental design Laboratory experience is desirable Experience with Python and/or MATLAB is highly desirable. Excellent English communication skills, including scientific writing and presentations. So, what’s next? Apply today and take the chance to be part of making a difference, making connections, and gaining the tools and experience to open doors and fulfil your potential. We can't wait to hear from you! We welcome your application as soon as possible, but ahead of the scheduled closing date October 29, 2026. In the event that we identify suitable candidates ahead of the scheduled closing date, we reserve the right to withdraw the vacancy earlier than published. Date Posted 08-okt.-2026 Closing Date 29-okt.-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

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24 Oct, 2026

Astrazeneca

Communications Coordinator

Australia – New South Wales

Salary not listed

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Communications Coordinator

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