Compensation: $120,000 - $170,000 Role Overview The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions. Key Responsibilities Provide structural biology support for variant analyses through structure-function relationship interpretation. Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms. Partner with statisticians and data scientists to validate algorithms and data collection workflows. Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects. Write testable, production-grade code adhering to SDLC standards and code review best practices. Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff. Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion Support, inform, and educate leadership and stakeholders about project progress and blockers. Qualifications & Competencies Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent. Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience. Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM). PRIVACY NOTICES To review Ambry’s Privacy Notice, Click here: https://www.ambrygen.com/legal/privacy-policy To review the California privacy notice, click here: California Privacy Notice | Ambry Genetics To review the UKG privacy notice, click here: California Privacy Notice | UKG Equal Opportunity Employer This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor. Tempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics. We built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make sure patients are on the right drug at the right time, so they can live longer and healthier lives. We’re looking for people who can change the world. Who question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.

Structural Biologist III.

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