Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. The Real World Evidence (RWE) group within the Life Sciences R&D team at Tempus works with major pharmaceutical partners to provide best-in-class data, analysis, and methodological guidance for Tempus’s real-world data offering. We are seeking a highly motivated and solutions-oriented RWE Data Scientist II with experience and interest in oncology and epidemiological study design to join our team. This role requires the ability to lead observational studies, derive insights from complex real-world clinical data, implement advanced statistical methods, and leverage cutting-edge AI tools to scale tasks and augment insights. Key Responsibilities Pharma Collaboration & Strategy: Partner with pharmaceutical collaborators to independently execute robust RWE research plans that leverage the Tempus multimodal platform to address key questions in trial design and outcomes research. Real World Data Expertise: Lead the derivation of complex real-world endpoints using extensive coding, demonstrating deep comprehension of Tempus clinical and molecular data structures and complexity, while also serving as an expert on the methodological nuances and limitations of real-world data. Methodology & Platform Contribution: Stay up-to-date on methodological advancements in real-world studies (e.g., causal inference, survival analysis) and oncology guidelines (NCCN and ongoing clinical trials) to contribute to reusable code, internal packages, and best practices that can be applied across multiple collaborations. AI & LLM Innovation: Incorporate LLMs, agentic workflows and other AI tools into day-to-day workflows to accelerate code development, discovery, documentation, review, and insight generation. Scientific Interpretation & Communication: Interpret results of RWE analyses to draw appropriate inferences based on study design/statistical methods, while also evaluating study limitations. Communicate complex methods and results clearly to both technical and non-technical stakeholders. Prepare and present internal reports, external-facing deliverables, and, where appropriate, manuscripts or conference materials. Cross-Functional Collaboration: Collaborate with internal product, oncology, and clinical abstraction, and real-world data science teams to continually enhance Tempus data quality, products, and analytical best practices. Minimum Qualifications Education: Education in epidemiology, biostatistics, data science, public health, or a related field, to the level of either: PhD Master’s degree and 2+ years of additional work experience Technical and Statistical Proficiency Proficiency with observational real-world healthcare data, including analytical experience with time-to-event methodologies (survival analysis). Proven expertise in executing RWD analytical studies. Proficient in using R and SQL, especially statistical tools and packages. Proficiency applying machine learning, LLM-based coding assistants (e.g., Claude Code, Copilot, Cursor) and agentic frameworks to support data analysis, code review, or scientific documentation workflows. Adherence to good software engineering practices (version control, modular code, documentation). Communication & Client Focus: Demonstrated experience interfacing with clients, showcasing adeptness in presenting and tailoring messaging to a variety of stakeholders. Soft Skills: Excellent written and verbal communication skills with strong project management skills. Ability to thrive in a fast-paced, dynamic environment working with multi-disciplinary scientists on complex problems. Preferred Skillsets Experience working with Pharma or drug development. Experience in clinical trial design (particularly Phase II-III) in the clinical development space. Analytical proficiency with claims, EHR, or registry data. Practical experience configuring or adapting LLMs, or using related tools/frameworks, to support scientific work. Knowledge of oncology guidelines (e.g., NCCN). Experience with biomarker or molecular data (e.g., genomics). Experience with cloud platforms such as AWS and/or BigQuery and/or Google Cloud Platform (GCP). #LI-DA1 USA: $100,000-$140,000 NYC/SF: $110,000-$150,000 The expected salary range above is applicable if the role is performed from California and may vary for other locations (Colorado, Illinois, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. Additionally, for remote roles open to individuals in unincorporated Los Angeles – including remote roles- Tempus reasonably believes that criminal history may have a direct, adverse and negative relationship on the following job duties, potentially resulting in the withdrawal of the conditional offer of employment: engaging positively with customers and other employees; accessing confidential information, including intellectual property, trade secrets, and protected health information; and appropriately handling such information in accordance with legal and ethical standards. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law, including the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Tempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics. We built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make sure patients are on the right drug at the right time, so they can live longer and healthier lives. We’re looking for people who can change the world. Who question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.

Data Scientist II, Real World Evidence, Life Sciences R&D.

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