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Who we are ? We are Pierre Fabre Laboratories, a global leader combining pharmaceutical expertise with dermo-cosmetics to support consumers and patients at every stage of their care journey. Our portfolio includes several medical franchises and international brands such as Eau Thermale Avène, Ducray, A-Derma, Klorane, René Furterer, and Pierre Fabre Oral Care. By joining us, you become part of a meaningful company where the human dimension is essential. You become a participant in the "We Care Movement," a movement that values excellence and innovation within passionate teams. Together, we push the boundaries of science to unite health and beauty for the benefit of all, because Every time we care for a single person, we make the whole world better. Present in 120 countries with a team of over 10,000 employees, we are proud to create a scientific and human impact, today and tomorrow! If caring is at the heart of your values, join Pierre Fabre Laboratories and become a key player in the “We Care Movement". Your mission We are seeking a Senior Quantitative Clinical Pharmacology Lead to join the Pharmacokinetics and Toxicology team within the Pierre Fabre R&D Pharma in Toulouse (Langlade site, Oncopole, France). In this high-impact strategic role, you will bridge the continuum between early translational pre-IND activities and late-stage regulatory and clinical successes. You will leverage deep clinical pharmacology expertise with an advanced understanding of Model-Informed Drug Development (MIDD) to drive data-driven decision-making, deliver efficacious therapies, and maximize the potential of our pipeline, focusing heavily on oncology, with expanding opportunities in rare disease and dermatology. Your role within a pioneering company in full expansion: Strategic Matrix Leadership: Serve as the core Clinical Pharmacology and translational PK/PD Function Lead on cross-functional matrix asset teams. Collaborate closely with Toxicology, Clinical Development, Translational Medicine, Biostatistics, CMC, and Regulatory Affairs to steer program strategies. Lead and execute the clinical pharmacology development plans from pre-IND through approval and life-cycle innovation. MIDD Strategy & Oversight: Drive the Model-Informed Drug Development (MIDD) strategy for asset teams. Translate program needs into actionable modeling plans, closely collaborating with the internal quantitative modellers and / or external Contract Research Organizations (CROs) to deliver high-quality MIDD analyses (including PopPK, PK/PD, exposure-response, PBPK, TGI-OS, and MBMA). Therapeutic Expertise Application: Apply deep clinical pharmacology principles to address complex challenges unique to oncology (e.g., dose-optimization paradigms, combinations), rare disease (e.g., small sample sizes, innovative trial designs), and dermatology. Trial Design & Execution: Lead the clinical pharmacology design of first-in-human and dedicated clinical pharmacology trials. Provide expert scientific oversight for protocols, investigator brochures, and clinical study reports. Regulatory Interaction: Author and review high-quality clinical pharmacology sections for global regulatory interactions (IND, NDA, BLA briefings) and serve as the functional expert in meetings with health authorities. Business Development Opportunities: Conduct rigorous clinical pharmacology and quantitative due diligence on external business development opportunities, assessing the quality of the evidence, MIDD strategy, and clinical viability of assets of interest, in the context of the competitors landscape. Who you are ? Your skills at the service of innovative projects: Education: Ph.D., Pharm.D., or M.D. in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or a highly quantitative biomedical field. Experience: 5+ years of pharmaceutical or biotech industry experience within clinical pharmacology and translational PK/PD. Therapeutic Track Record: Proven experience driving clinical pharmacology strategies in oncology is highly preferred; additional experience in rare diseases or immunology/dermatology is a distinct advantage. Advanced MIDD Literacy & Management: Modeling literacy with the ability to conceptualize, interpret, and defend quantitative strategies (e.g., PopPK, E-R, QSP). Demonstrated experience managing internal modellers and managing external vendors/CROs is highly desirable. Modality Versatility: Expertise in the development of small molecules and biologics is highly desirable; experience with advanced or emerging modalities is a distinct advantage. Leadership & Communication: Outstanding written and verbal communication skills with a proven track record of translating complex quantitative concepts to non-modeling stakeholders and influencing strategic decisions in matrix environments. What We Offer A dynamic, science-first culture dedicated to oncology and precision therapeutic, and the opportunity to lead strategies across diverse modalities and indications. Competitive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation... This position is compatible with teleworking up to 2 days a week according to company rules. Ready to lead the future of Model-Informed Drug Development at Pierre Fabre? Apply today! At Pierre Fabre Laboratories, we believe that our greatest asset is our people. We are committed to a policy of Equal Employment Opportunity and will not discriminate against an applicant or employee based on race, color, religion, creed, national origin or ancestry, sex, sexual orientation, gender identity or expression, age, physical or mental disability, veteran or military status, genetic information, or any other legally recognized protected basis under federal, state, or local law. The information collected by this application is solely to determine suitability for employment, verify identify, and maintain employment statistics on applicants. Applicants with disabilities may be entitled to reasonable accommodation under the Americans with Disabilities Act and certain state or local laws. Please inform the company’s personnel representative if you need assistance completing this application or to otherwise participate in the application process. Thus, we commit to considering all applications equally, without fail. Pierre Fabre Laboratories is the world’s second-largest dermo-cosmetics company and one of Europe’s leading pharmaceutical laboratories. Our Dermo-cosmetics & Personal Care portfolio includes international brands such as Eau Thermale Avène, Ducray, Klorane, A-Derma, René Furterer, Même Cosmetics, Darrow and Elgydium. The Medical Care activity covers 5 main therapeutic fields: oncology, dermatology, rare diseases, primary care and family health care. By choosing Pierre Fabre Laboratories, you will join a company where the human dimension is essential, where excellence and innovation are valued, within passionate teams united by common values, committed to pushing the boundaries of science to unite health and beauty for the benefit of all, because every time we care for a single person, we make the whole world better.
pierrefabre
France - Toulouse - Langlade, France
Senior Quantitative Clinical Pharmacology Lead- CDI- H/F.
SENIOR LEVEL