Staff/Senior Staff/Principal Electrical Systems Engineer At PacBio we create the world’s most advanced sequencing systems to provide the most complete and accurate view of genomes, transcriptomes, and epigenomes. Our founders invented a new way to study the synthesis and regulation of DNA, RNA, and proteins. Driven by a desire to advance human health, we’re harnessing advances in biochemistry, optics, nanofabrication, and more. Our mission is to enable the promise of genomics to better human health. Position Summary You will oversee the electrical system architecture of complex DNA sequencing instruments. This highly technical, hands-on role spans system architecture, board-level electronics, power and signal distribution, cabling and harnessing, while collaborating with firmware, software, manufacturing, new product introduction, quality, and service to deliver robust, reliable, scalable, and production-ready instrument designs. Responsibilities Create and maintain instrument system level electronic block diagrams. Define, design, document, prototype, and validate cables and wire harnesses, including connector selection, pinouts, wire and shielding requirements, grounding, signal integrity, mechanical routing constraints, and test requirements. Work with internal technicians and external suppliers to transition cable designs into production. Design, prototype, bring up, debug, modify, and validate complex mixed-signal circuit boards incorporating embedded processors and microcontrollers, high-speed digital interfaces, programmable logic (FPGAs), power electronics, motor and actuator drivers, and sensor interfaces. Collaborate closely with other teams including firmware, software, sequencing integration, consumables, mechanical, optical, fluidics, thermal, manufacturing, quality, service, and others to define interfaces and deliver fully integrated instrument designs. Lead system-level troubleshooting and root-cause investigations involving interactions of electrical hardware, firmware, software, mechanical and optical systems, etc. Implement design and process improvements that increase instrument reliability and manufacturability. Own and analyze electrical system performance margins, including power integrity, grounding, shielding, noise, ESD, EMI/EMC, high-speed signal integrity, timing, thermal loading, motor and actuator control, and sensor signal quality across operating conditions and production variation. Plan and lead design reviews. Partner with NPI, Manufacturing, Supply Chain, and suppliers to document designs for production, including component selection and lifecycle management, DFx considerations, manufacturing test strategy, prototype and production builds, and post-launch issue resolution. Ensure electrical designs comply with applicable regulatory, safety, EMC, and environmental requirements, including UL, CE, FCC/EMC, IEC, FDA, and ISO requirements as applicable to laboratory and clinical instrumentation. Lead or contribute to electrical and system-level failure mode and effects analyses (FMEA) and drive appropriate risk mitigations into the design. Stay current with emerging technologies including processors, FPGAs, sensors, high-speed interconnects, control buses including USB, CAN, and EtherCAT, power electronics, and communications technologies, and apply them where they improve instrument performance, reliability, scalability, or cost. Required Qualifications Bachelor's degree or higher in Electrical Engineering, Computer Engineering, or a related discipline. Typically requires a minimum of 7-14+ years of related experience with a Bachelor’s degree; or a minimum of 5-12+ years with a Master’s degree; or a minimum of 3-11+ years with a PhD. Strong hands-on experience with schematic capture and PCB design/layout using Altium, Cadence, or similar professional EDA tools, including review of multilayer and mixed-signal PCB designs. Past experience incorporating communication protocols and interfaces such as USB, CAN, or EtherCAT in electronic architectures. Experience working with suppliers and manufacturing partners on PCB layout, component selection and availability, fabrication, assembly, prototype builds, and production release. Demonstrated strength in cable and harness architecture, design, documentation, prototyping, and sourcing. Strong laboratory and troubleshooting skills, including experience with oscilloscopes, logic analyzers, DMMs, power supplies, or similar electrical test equipment. Excellent interpersonal, written, and verbal communication skills, with the ability to lead technical discussions and work effectively across engineering and operational organizations. Preferred Qualifications Experience developing life science, medical, diagnostic, semiconductor, robotics, or other complex scientific instruments combining electronics, firmware, software, optics, motion control, fluidics, thermal control, high-speed electronics, and high-speed data transmission. Experience with high-speed digital interfaces such as Ethernet, PCIe, USB, DDR, or other multi-gigabit serial interfaces, including signal-integrity considerations. Experience with FPGA-based systems and close collaboration with FPGA/RTL engineers. Experience with precision motion control, motors, encoders, sensors, and electromechanical control systems. Experience with EMC/EMI design and troubleshooting, safety certification, and regulatory requirements for laboratory or clinical instrumentation. Experience with product lifecycle management (PLM), configuration control, engineering change orders, and formal design documentation in a regulated or quality-controlled product-development environment. Experience supporting NPI, manufacturing scale-up, reliability improvement, serviceability, and sustaining engineering for complex products. The title and salary will be determined during the hiring process based on the candidate’s experience. Candidates must have current authorization to work in the United States without the need for present or future sponsorship. Non-Field Based Employees are required to be onsite Monday–Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite. You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties. All listed tasks and responsibilities are deemed essential functions of this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, disability, gender identity, or sexual orientation. #LI-Onsite Salary Range: $148,200.00 - $293,900.00 To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or careers@pacificbiosciences.com for assistance. Visit our following pages for more information on: FAQs Benefits Culture Equal Opportunity Employment Beware of Recruitment Fraud Please be aware of employment scams where people or entities misuse PacBio’s name, or the names of PacBio employees, to post fake job advertisements or make fake job offers. PacBio will never extend a job offer without a personal interview and will never charge any money for joining our company. All current job openings are displayed on the Careers page of our official website. If you see a job posting that is not on the PacBio official website, or have been approached with a job offer that you suspect may be fraudulent, we strongly recommend you do not respond and do not send money or provide any personal information. IT IS LIKELY A SCAM OR FAKE JOB AD IF: The job offer requires you to pay something (for example, to purchase equipment). You receive a job offer that you didn’t apply for, or without a personal interview or interaction. The interview seems to involve AI video or audio. You found a job on a job board or third-party channel, but the job doesn’t exist on the official PacBio careers page You suspect it is a scam. HOW TO PROTECT YOURSELF: Never give personal and confidential information. Never pay for anything as part of interviewing for, or accepting, an offer of employment. Ignore it if it seems like a scam. At PacBio, we’re all on a mission to enable the promise of genomics to better human health. It’s what fuels us every day. Our team is passionate about catalyzing scientists pursuing biological discoveries, and we’re looking for exceptional individuals like you to join us. If you’re interested at being at the intersection where health and technology come together, then consider joining our team. We look forward to meeting you. CORE VALUES: BE CURIOUS. Our future depends on it. DELIGHT OUR CUSTOMERS. We strive to get it right every time. TAKE ACTION. We move fast and take calculated risks. EXECUTION MATTERS. Our customers rely on us. WORK TOGETHER. We care deeply about each other. Please be aware of employment scams where people or entities misuse PacBio’s name, or the names of PacBio employees, to post fake job advertisements or make fake job offers. PacBio will never extend a job offer without a personal interview and will never charge any money for joining our company. All current job openings are displayed on the Careers page of our official website. If you see a job posting that is not on the PacBio official website, or have been approached with a job offer that you suspect may be fraudulent, we strongly recommend you do not respond and do not send money or provide any personal information. IT IS LIKELY A SCAM OR FAKE JOB AD IF: The job offer requires you to pay something (for example, to purchase equipment). You receive a job offer that you didn’t apply for, or without a personal interview or interaction. The interview seems to involve AI video or audio. You found a job on a job board or third-party channel, but the job doesn’t exist on the official PacBio careers page You suspect it is a scam. HOW TO PROTECT YOURSELF: Never give personal and confidential information. Never pay for anything as part of interviewing for, or accepting, an offer of employment. Ignore it if it seems like a scam.

Staff/Senior Staff/Principal Electrical Systems Engineer.

more at Pacbio.

Senior Genomic Sales Specialist

Staff Engineer, Software (Deployment)

Senior Engineer, New Product Introduction (Metrology)

similar roles.

Member of Technical Staff, Data Infrastructure Storage

Junior Database Administrator

Senior Systems Engineer

Mechanical Systems Engineer

Senior Database Administrator

Specialist, Databricks Platform Engineer