Drug discovery has benefitted enormously in the current AI era yet comprises only a portion of the journey to bring new treatments to those in need. The final step – clinical drug development – is oft overlooked, despite requiring a significant proportion of time and investment. In the AI for Clinical Development team at AstraZeneca, we're reimagining the process of clinical development. Our vision is to bring safe, efficacious treatments to patients in a way that quantifiably improves our chance to do this faster, more cost-effectively, and with reduced patient burden. In this role, you will be a technical lead to help us leverage the power of AI to the fullest, alongside our other computational, statistical, and machine learning tools. You will work across the enterprise to define and deliver on AstraZeneca’s most pressing clinical development questions. You will proactively collaborate in cross-functional teams spanning AstraZeneca’s key Oncology foci of hematology, cell therapy, antibody-drug conjugates, small molecules, and biologics. This is an unprecedented, high visibility opportunity to invent new ways to leverage data, models, and learnings across the spectrum of cancer biology and drug modalities – and importantly, you and the team will apply these new methods to measurably advance the late-stage drug pipeline and our group’s ambition. Responsibilities: Contribute to the AI strategy and roadmap for Oncology early and late phase clinical development Serve as a key technical lead and contributor in matrixed teams to deliver complex, high-stakes AI projects Evaluate and develop cutting-edge AI methods in one or more areas of problem definition, data considerations, governance, algorithm development, validation, and adoption Partner with clinical development, biometrics, regulatory, and study teams to develop and then validate novel AI solutions into clinical study design, execution, strategy, and decision-making Establish and maintain external collaborations with academic institutions, technology partners, and industry consortia to access novel capabilities and advance the AI roadmap Represent AstraZeneca at scientific conferences, standards bodies, and peer-reviewed venues; contribute first- or last-author publications in leading ML and clinical AI journals Mentor and support peers within the team Qualifications: PhD in a quantitative discipline such as computer science, bioinformatics, computational biology, mathematics, physics, biophysics, computational neuroscience, biostatistics At least 2+ years’ work experience outside of PhD with measurable impact (e.g. models delivered, patents, SaMD filings, first-author publications, open-source projects, standards-body participation) Technical requirements: Exceptional software development and coding skills, leveraging frontier coding agent frameworks; knowledge of computing hardware a plus Deep understanding of machine learning fundamentals, with domain expertise in one or more of the following - Training and tuning foundation models Bayesian inference Temporal modeling Multimodal integration and modeling Model calibration and domain adaptation Data-centric AI: acquiring, creating, and curating datasets for model training / post-training / benchmarking / evals Model and data evaluations and benchmarking Model interpretability Model post-training and alignment Preferred Skills: Deep up-to-date knowledge of ML literature and connections with the ML community (e.g. conference publications, presentations, or collaborations) Experience, knowledge, and understanding of one or more fields of biology Experience working with biological data such as molecular (e.g. DNA, RNA, protein), imaging (radiology, microscopy), or clinical text (e.g. EHR, clinical notes) Experience in drug development including but not limited to clinical trial design, biomarker discovery, companion diagnostics, dosing, safety, endpoints, and regulatory Experience in a matrixed global organization spanning multiple sites and therapy areas Up to date with the latest AI research and tools, proactively trying out those of interest, and ability to discern hype from true added value #EAI The annual base pay for this position ranges from $144K to $216K. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 21-Oct-2026 Closing Date 30-Oct-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

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