Location ST. LOUIS, MO 63108 Scheduled Hours 40 Position Summary We are seeking a highly motivated scientist to join our functional genomics team at the Goldfarb Center for Neuronal Resiliency at the McDonnell Genome Institute, WashU Medicine. The Goldfarb Center for Neuronal Resiliency was established to identify new therapeutic targets and treatments for neurodegenerative diseases, particularly ALS and Parkinson’s disease. Central to this effort are CRISPR screens that identify genes that make neurons more vulnerable or resilient to stress. These screens will use human induced pluripotent stem cell (iPSC)-derived neuronal models of neurodegenerative diseases. Work in the lab also integrates CRISPR perturbations with phenotypic assays and molecular readouts using flow cytometry, high content imaging, next-generation sequencing, and single-cell, spatial, and in situ profiling. About The Goldfarb Center for Neuronal Resiliency Led by Drs. Jeff Milbrandt and Rob Mitra, The Goldfarb Center for Neuronal Resiliency is a highly collaborative and interdisciplinary research environment integrating functional genomics, stem cell engineering, neuroscience, high throughput imaging, next-generational sequencing, artificial intelligence, and drug discovery. Our work is inspired by the observation that neurodegeneration is strikingly selective for specific neuronal populations. For example, in ALS, motor neurons degenerate while neighboring interneurons remain intact. Even within motor neurons, some subtypes are highly vulnerable, while others are resilient. We believe these differences in resiliency provide clues to new therapeutic strategies that have yet to be harnessed for drug development. Specifically, our long-term goal is to discover therapeutics that activate resiliency factors or inhibit vulnerability factors in diseased neurons in order to restore them to heath and reverse the progression of these debilitating diseases. Job Description Primary Duties & Responsibilities: For more about this project, visit https://genome.wustl.edu/the-resiliency-project-advancing-neurodegenerative-disease-research-at-mgi/. Working Conditions: Because some cell culture, differentiation, and time-sensitive experimental workflows require procedures on specific days, the successful candidate must be able to accommodate occasional weekend work when required by experimental schedules. This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment. Salary Range: Base pay is commensurate with experience. The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time. Required Qualifications Education: Bachelor’s degree or combination of education and/or experience may substitute for minimum education. Certifications/Professional Licenses: No specific certification/professional license is required for this position. Work Experience: No specific work experience is required for this position. Skills: Not Applicable Driver's License: A driver's license is not required for this position. More About This Job Preferred Qualifications: Candidates with a bachelor's, master's degree, or PhD will be considered. Substantial research experience in molecular biology, cell biology, genetics, genomics, neuroscience, bioengineering, or a related field. Strong hands-on experience in mammalian cell culture and molecular biology. Strong organizational skills and ability to manage multiple experiments and priorities. Strong written and verbal communication skills. Preferred Experience: Experience in one or more of the following areas would be highly desirable: CRISPR/Cas genome editing, CRISPR screening, or functional genomics. Human iPSC culture and differentiation, particularly neuronal differentiation. Lentiviral vector production and transduction. Flow cytometry and fluorescence-activated cell sorting (FACS). Reporter assay development and engineered stable cell lines. qRT-PCR and Western blotting. DNA/RNA purification, PCR, cloning, and other molecular biology techniques. Next-generation sequencing and sequencing-library preparation. Experience with every technique listed above is not required. Candidates with a strong foundation in mammalian cell and molecular biology, demonstrated scientific independence, and the ability to rapidly learn new technologies are encouraged to apply. Final appointment and title will be commensurate with the candidate's qualifications and experience. Preferred Qualifications Education: No additional education unless stated elsewhere in the job posting. Certifications/Professional Licenses: No additional certification/professional licenses unless stated elsewhere in the job posting. Work Experience: No additional work experience unless stated elsewhere in the job posting. Skills: Communication, Laboratory Research, Organizing, Recordkeeping, Working Independently Grade 00 Salary Range Base pay is commensurate with experience. The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget. Questions For frequently asked questions about the application process, please refer to our External Applicant FAQ. Accommodation If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship. Pre-Employment Screening All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits Statement Personal Up to 22 days of vacation, 10 recognized holidays, and sick time. Competitive health insurance packages with priority appointments and lower copays/coinsurance. Take advantage of our free Metro transit U-Pass for eligible employees. WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%. Wellness Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more! Family We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? We’ve got you covered. WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us. For policies, detailed benefits, and eligibility, please visit: https://hr.wustl.edu/benefits/ EEO Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity or shared ancestry, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. As a federal contractor, the university maintains affirmative action programs to implement its equal employment opportunity policy for individuals with disabilities and protected veterans, in accordance with Section 503 of the Rehabilitation Act of 1973, as amended, and the Vietnam Era Veterans’ Readjustment Assistance Act of 1974 (VEVRAA), as amended. Q: Can I create a job alert to notify me when jobs of interest are posted? A: Yes! After you create a Candidate Home account, you can set up and manage job alerts to be sent to you either daily or weekly, according to the filters you select. You can add, edit, or delete job alerts at any time. You will need to opt in to communications from WashU when you set up your first alert and will only receive alerts for jobs posted after the alert has been created. Set alerts today so you do not miss any new opportunities! Washington University in St. Louis' collective success is significantly attributed to the passion and outstanding efforts of our community. Our staff, faculty and trainees are committed to excellence and dedicated to carrying out our missions of research, teaching and patient care. WashU prides itself on being a place where people matter, and serious work is done. Our people work together in an inclusive community that celebrates diverse perspectives, collaboration and innovation. We are a community of individuals inspired to work together to develop big ideas and tackle challenging problems. We value the well-being of our people. WashU strives to create a positive employee experience where staff, faculty and trainees thrive, both personally and professionally. Our employees find meaning, connection and vitality in their work and life with a healthy work-life balance and support to learn, grow and make an impact at WashU, the community and the world. Useful Links Who We Are Human Resources Benefits Living in St. Louis Frequently Asked Questions Accommodation If you are unable to use our online application system and would like an accommodation, please email CandidateQuestions@wustl.edu or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. Regulatory Postings Know Your Rights: Workplace Discrimination is Illegal Poster (English; Spanish)

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